Is PRP Therapy More Effective Than a Traditional Cortisone Injection?

Medically Reviewed Reviewed by DR JOHN PRP
This article has been reviewed for medical accuracy by a licensed physician with experience in integrative health.

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When faced with chronic joint pain or soft tissue injuries, patients are often offered a choice between traditional cortisone injections and regenerative approaches like PRP therapy. Both have their place in orthopaedic care, but they work in fundamentally different ways. So, how do you decide between PRP vs cortisone injection?

Understanding the Difference

Cortisone injections are widely used in orthopaedics to manage inflammation and pain. They offer fast relief by suppressing the body’s inflammatory response, which can be particularly helpful in acute flare-ups of conditions like shoulder tendonitis or knee osteoarthritis. However, cortisone does not contribute to long-term healing and repeated use may weaken tissues over time.

On the other hand, PRP therapy uses a concentration of your own platelets to encourage healing at the site of injury. It works by releasing growth factors that support tissue repair, making it a more regenerative option rather than just a symptom suppressor.

Effectiveness: What the Research Says

Studies comparing PRP vs cortisone injection show varied outcomes depending on the condition being treated. For example:

  • In knee osteoarthritis, PRP may offer longer-lasting relief than cortisone, with some patients reporting symptom improvement for up to 12 months.
  • For chronic tendon issues like tennis elbow, PRP has shown promising results in promoting healing, whereas cortisone may provide only temporary relief.

That said, cortisone can still be valuable in cases where immediate pain relief is needed, especially in acute or severe inflammation.

Short-Term vs Long-Term Outcomes

Cortisone typically provides faster results, often within 48 hours. However, the effect may wear off within a few weeks or months, especially in cases of chronic degeneration. PRP therapy may take longer to show noticeable improvements—often a few weeks after the injection—but the benefits may last longer and address the root of the problem.

Side Effects and Considerations

While cortisone is effective, repeated use can increase the risk of cartilage damage, tendon weakening, or joint space narrowing. PRP therapy, being autologous (from your own body), carries a lower risk profile and is considered safer for repeated use over time.

Choosing the Right Option for You

The choice between PRP and cortisone depends on your goals, health status, and the nature of your injury. If immediate symptom relief is the priority, cortisone might be considered. If long-term healing is your focus, PRP may offer a more sustainable path.

Expert Tip

Consider PRP therapy if you’re looking to promote natural healing and reduce the need for repeated cortisone injections that may affect tissue health long-term.

Key Takeaways

  • Cortisone injections suppress inflammation and offer quick relief, but may not support long-term healing
  • PRP therapy encourages tissue repair and may offer more sustainable outcomes for certain conditions
  • PRP may be a better option for chronic injuries or patients seeking natural regenerative support

References

  • Australian Journal of Musculoskeletal Medicine. (2021). Comparative Outcomes of PRP vs Cortisone in Orthopaedics.
  • Filardo G, et al. (2018). PRP and Corticosteroid Injections for Knee Osteoarthritis: A Comparative Review. Am J Sports Med.
  • Regenerative Medicine Australia. (2022). The Growing Role of PRP in Joint and Tendon Therapy.
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