Platelet-Rich Plasma (PRP) therapy is a growing area of interest in regenerative medicine, especially for those dealing with persistent joint, tendon, or ligament pain. Many patients considering orthopaedic PRP wonder: is PRP a permanent solution, or will I need follow-up injections? The answer depends on several factors including the condition being treated, the severity of the injury, your overall health, and how your body responds to the regenerative process. While some patients may experience lasting benefits from a single treatment, others might require a series of PRP injections to maintain relief.
Understanding How PRP Works
PRP therapy involves injecting a concentrated sample of your own platelets directly into an injured area. These platelets contain growth factors that support tissue repair and reduce inflammation, offering a natural alternative to traditional treatments. This process aims to promote long-term healing rather than merely masking symptoms. However, as with any treatment, outcomes can vary based on individual circumstances.
In orthopaedic settings, PRP is used to address a wide range of conditions including knee arthritis, shoulder tendonitis, ligament tears, muscle strains, and chronic tendon pain. It is also commonly applied after sports injuries or during rehabilitation.
How Long Do the Effects of PRP Last?
Many patients report symptom improvement within a few weeks, with effects that can last several months or even longer. However, PRP is not considered a permanent solution in the same way that surgical reconstruction or joint replacement might be. Instead, it works with your body’s healing mechanisms to potentially slow degeneration or aid recovery from soft tissue damage.
For some conditions, such as early-stage osteoarthritis, a single PRP injection may provide significant relief for up to 6–12 months. In contrast, more advanced degeneration or chronic issues may benefit from a course of treatments spaced over several weeks or months.
When Are Follow-Up PRP Injections Needed?
Your response to initial treatment is the best guide. Follow-up injections may be recommended based on:
- Severity of the condition – Advanced or long-standing conditions may require more than one injection to achieve sustained results.
- Activity level – Active individuals or athletes may place greater stress on healing tissues, requiring additional support.
- Treatment goals – Some patients seek PRP to reduce pain and inflammation, while others aim to delay surgery or improve joint function. These goals can influence the number of treatments required.
Your orthopaedic provider will assess your progress and discuss the potential benefits of repeating the therapy. In many cases, PRP injections are spaced apart strategically to avoid overstimulation of tissue while still encouraging healing.



