Are There Any Risks or Side Effects Associated with PRP Therapy?

Medically Reviewed Reviewed by DR JOHN PRP
This article has been reviewed for medical accuracy by a licensed physician with experience in integrative health.

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While PRP therapy has gained popularity in orthopaedic care for its natural healing approach, it’s important for patients to understand the potential risks involved. Whether you’re considering PRP for knee pain, tendon injuries, or joint degeneration, knowing what to expect and how your body might respond is a crucial part of the decision-making process.

What Are the Risks of PRP Therapy?

PRP therapy is generally considered safe because it uses your own blood, reducing the chance of allergic reaction or rejection. However, as with any medical procedure, there are potential side effects to be aware of. Most of these are mild and temporary.

Common Side Effects

  • Mild pain or discomfort at the injection site
  • Localised swelling or stiffness for a few days
  • Bruising where the blood was drawn or injected
  • Temporary increase in inflammation during the body’s healing response

These side effects are usually short-lived and manageable with simple aftercare, allowing most patients to return to light activities within a day or two.

Less Common but Possible Risks

Though rare, there are other risks associated with PRP injections, including:

  • Infection at the injection site
  • No improvement in symptoms despite treatment

These risks are significantly minimised when the procedure is performed by an experienced clinician using sterile techniques and appropriate imaging guidance.

Who Should Be Cautious?

Certain individuals may not be suitable candidates for PRP treatment. These include people with:

  • Active infection
  • Blood clotting disorders
  • Low platelet counts
  • Certain autoimmune conditions

It’s essential to have a comprehensive evaluation before proceeding with PRP to ensure it’s the right treatment for your condition.

Expert Tip

Always ask whether your clinician uses ultrasound guidance for your PRP injection—it improves accuracy and reduces the risk of complications.

Key Takeaways

  • PRP therapy risks are generally mild and include temporary discomfort, swelling, or bruising
  • More serious complications are rare, especially when performed by a qualified PRP doctor
  • Proper screening and preparation reduce the chances of adverse effects and ensure safer outcomes

References

  • Australian Journal of General Practice. (2021). PRP Therapy: Applications and Safety Considerations.
  • Mishra A, et al. (2019). Platelet-rich plasma: current concepts and application in sports medicine. Br J Sports Med.
  • Orthopaedic Research Australia. (2023). Understanding the Use and Safety of PRP in Clinical Practice.
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